Endocrine Abstracts

Breast cancer (BCa) patients who present at clinic with elevated circulating LDL-cholesterol have poor prognosis, whilst pharmacological and lifestyle interventions that lower circulating cholesterol (statins, exercise, low saturated fat intake etc.) are associated with better treatment efficacy. The molecular mechanisms that link cholesterol with chemotherapy resistance (CR) remain unexplored. Hydroxycholesterols (OHCs) activate the transcription factor LXR, and are formed in...

Triple negative breast cancer (TNBC) represents 10–20% of all breast cancers diagnosed, affects young people and is highly aggressive. These tumours lack expression of the receptors that bind estrogen and progesterone and stratify patients for hormonal therapy. The only current therapeutic option for TNBC is chemotherapy which has limited efficacy, and therefore novel therapies are desperately needed. The receptors for estrogen and progesterone belong to the nuclear recep...